Is it safe to delete the Killing Floor 2 folder in My Games?

Yes. It is not the install folder. It holds your configuration, and the game recreates it on the next launch.

What do I lose by deleting it?

Your settings go back to defaults, and in some cases you need to re-equip weapon skins from the inventory.

KF2 BugSplat Crash: Delete the My Games Folder

This page is a translation of a short Spanish guide for the "BugSplat" error, the crash reporter window that appears when Killing Floor 2 fails to start or closes on launch. The author says the method worked for them and for friends they passed it to.

The fix

Close the game completely.
Open Documents and then the My Games folder.

My Games folder in Documents Documents, My Games: here you will find a Killing Floor 2 folder.

Delete the entire Killing Floor 2 folder, then start the game again.

Killing Floor 2 folder to delete This folder only contains your configuration, not the game installation.

Do not worry: this is not the folder where the game is installed. It is the one that stores your settings and config files, and the game rebuilds it automatically.

Things to know

If you had a skin equipped on a weapon, you may need to equip it again from the inventory.
Several commenters confirmed that only wiping the configuration was enough for them.
Some readers also fixed the same error by installing DirectX (version 11), and one reported it helps to install the game on an SSD if the error keeps returning.
The error can appear on a fresh install on a new PC, so it is not always a sign of corrupted files.

For other causes and fixes see BugSplat launch crash fix with launch options and BugSplat error: config delete and driver rollback.

FAQ

Is it safe to delete the Killing Floor 2 folder in My Games?: Yes. It is not the install folder. It holds your configuration, and the game recreates it on the next launch.
What do I lose by deleting it?: Your settings go back to defaults, and in some cases you need to re-equip weapon skins from the inventory.